DR MUHAMMAD HARIS BURKI
MUHAMMAD ZUBAIR MUKHTAR
Presently psychiatry relies heavily on dysfunction in endogenous monoamine system hypotheses. Pathophysiogy of depression, anxiety, bipolar, schizophrenia is explained on bases of disturbance of neurotransmitters .Inflammatory products like cytokines have been implicated in pathophysiology of psychiatric disorders. Greater incidences of inflammatory disease in psychiatric disorder and increased incidence of psychiatric co morbidity in inflammatory disease ,suggest common underlying pathophysilogical process is at work. Role of anti-inflammatory agent has been investigated.
Internet search was made at various medical website including pub med using key words inflammation, inflammatory marker, depression, addiction, anti-inflammatory natural products. This followed by study of peer reviewed relevant articles.
Inflammatory mediators like IL-6,IL2, TNFalpha CRP are implicated in pathphysiology of psychiatric illness. Anti inflammatory agents including celecoxibs, minocycline, Nacetyle cystine ,turmeric, licorice can modify psychiatric disease process`
Inflammation can mediate transformation in brain cells. Cytokines can modify neurotransmitters, neural and glial plasticity across BBB. Oxidative stress is closely related to the inflammation .Oxidative stress effect methylation of DNA causing increase susceptibility of psychiatric disorder.
N accetyle cystine is precursors of glutathione, and has anti-inflammatory, antioxidant, homocystine reducing ,antiglumatergic and dopaminergic modulating properties. It has role in treatment of different type of addictions, bipolar disorder, schizophrenia, grooming disorder and OCD. Oxidative stress is cumulative effect of all pathways. N acetyle has emerged as promising adjuvant agent in treatment of psychiatric disorders.
Use of antoxidant and anti-inflammatory agent can be useful add on drugs for partial responders of psychiatric disorder